Endocrine Abstracts

I would like to present the case of a 66-year-old gentleman with McCune–Albright syndrome. This unusual condition consists of three main features; namely, polyostotic fibrous dysplasia, café au lait patches on the skin and hormonal abnormalities, including acromegaly.The presentation will look briefly at these three elements and the investigations leading up to diagnosis. However, the main focus will be on the psychological impact illness has h...

Background: Resistant Hypertension is defined as uncontrolled high BP despite treatment with at least three antihypertensive agents. The underlying cause is usually found to be phaeochromocytoma, Conn’s or renal artery stenosis (RAS). We would like to present two cases with difficult control of hypertension which did not fall into these categories.Case 1: History: 68 year old gentleman presented 2012 with >10 year history of hypertension. BP 200...

We present a 45-year-old lady who initially presented with neurological symptoms and MRI was noted to show asymmetry of the pituitary gland. There were no endocrine symptoms. In 2011 she developed some visual symptoms (not typical of pituitary disease) and was referred to the ophthalmic department. MRI scan showed an 11 mm right-sided pituitary lesion and she was referred to the endocrine department. She gave a 2-year history of feeling increasingly unwell with back pain, sens...

The low dose dexamethasone suppression test (LDDT) is used routinely to exclude Cushings. This test can also be used to exclude androgen secreting tumours in females with elevated testosterone levels through normalisation of, or >40% suppression of serum levels.We have audited the use of the LDDT to assess its value in investigating women with raised androgens, to ascertain whether it reduced the need for other investigations and to identify any prob...

We would like to present a case which, through unexpected results, caused us to examine the communication, both written and verbal, that is provided to patients prior to undergoing dynamic tests in our unit, and which subsequently led to a change in our practice.A 48-year-old lady was referred from the GP with a raised testosterone of 5.0 nmol/l (reference range 0.2–2.9 nmol/l), irregular periods and late onset hirsutism. A low dose dexamethasone te...

Background: Neuroendocrine tumours (NETs) are heterogeneous cancers with varied survival, arising mainly from the gastroenteropancreatic tract. Delayed diagnosis and mislabelling are widely recognised internationally in midgut NETs with little data describing how to improve diagnosis times. In 2017, transformation of the South Wales NET Service included a change to a gastroenterology-led service model alongside education and forming working relationships with gastroenterologis...